Protein Purification
MilliporeSigma™ Calbiochem™ JAK3 Inhibitor VI
The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Splitomicin
A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 μM).
MilliporeSigma™ Calbiochem™ InSolution™ Y-27632 in DMSO
InSolution™ Y-27632 is a 10mm solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140nM for p160ROCK).
MilliporeSigma™ Calbiochem™ Pravastatin, Sodium Salt
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ≈1 nM).
MilliporeSigma™ Calbiochem™ VEGFR2/Flt3/c-Kit Inhibitor
The VEGFR2/Flt3/c-Kit Inhibitor, also referenced under CAS 796967-10-7, controls the biological activity of VEGFR2/Flt3/c-Kit. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ Calcineurin Inhibitor VIII, CN585
The Calcineurin Inhibitor VIII, CN585, also referenced under CAS 1213234-31-1, controls the biological activity of Calcineurin. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Honokiol
A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.
MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246
A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ Luteolin
An antioxidant flavonoid and a free radical scavenger.
MilliporeSigma™ Calbiochem™ InSolution™ RNA Polymerase III Inhibitor
The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ KN-93, Water-Soluble
This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).
MilliporeSigma™ Calbiochem™ RAGE Antagonist Peptide, RAP
The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.
MilliporeSigma™ Calbiochem™ AEBSF, HCl ≥99% by HPLC
Specific irreversible inhibitor of serine proteases
MilliporeSigma™ Calbiochem™ CD40-TRAF6 Signaling Inhibitor, 6877002
A cell-permeable compound that specifically targets TRAF6 (Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40.